Biocatalysts Enzyme Manufacturing Plant
Biocatalysts Enzyme Manufacturing Plant

Fermentation Services

Modern biotechnology opens avenues to expand the use of microorganisms on an unprecedented scale to help build sustainable systems for healthy food production and scalable industrial biocatalysts.

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Scaling fermented solutions
Microbial- or Precision fermentation is known to be very scalable using different microbes to economically produce ingredients at large volumes. Precision fermentation will continue to play a significant role in the production of next generation food ingredients and supporting ingredients such as growth factors, enzymes, preservatives and peptides.
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Biocatalysts Enzyme Discovery
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Biocatalysts Enzyme Manufacturing Plant
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Fermentation Services at Biocatalysts

Our Enzyme Development Suite hosts a range of micro-fermentation technology at 0.5L and 3L fermenter volumes with dedicated scale down-stream processing development at laboratory scale. This suite enables our Team to fully optimise fermentation processes prior to transferring to larger volumes.

Your protein of interest and process can be seamlessly scaled up to 70L fermentation volume to confirm optimised fermentation conditions. The output from this phase is a fully scalable, optimised enzyme production process primed for production at commercial volumes.

As part of our manufacturing process the protein will go through an appropriate pilot scale up to 750L. We have industrial scale fermentation capacity of 2 x 10,000L and full downstream processing including, centrifugation, ultrafiltration, bactofiltration, chromatography, spray- and freeze drying capabilities. Onward capabilities to larger commercial scales of up to 63,000L can also be achieved.

Microorganism Strain Development & Optimisation

Fermentation as a scalable technology starts with the microorganism hosts that act as factories in which cells are capable of producing very precise ingredients through very rapid duplication. Fermenting proteins requires the synergy between protein of interest and microorganism strain. Different proteins, and even different classes of enzymes are known to be better suited to specific microorganisms. To achieve optimum fermentation expression of the protein, genetic engineering or evolutionary optimisation methods at BRAIN Biotech can be explored to best reach target strain productivity. For more information on BRAIN Biotech's discovery, development and optimisation of microbial strains, click below.

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20 May 2024
Biocatalysts Ltd Completes Scale Up of Speciality Enzyme for Large Pharmaceutical Company Utilising its New Chromatography Facility
Newly installed advanced chromatography system at Cardiff site enables the production of high-purity speciality enzymes.
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5 Mar 2024
Biocatalysts Ltd expands its Manufacturing Capabilities with Large-Scale Freeze Drying
This latest investment in large-scale freeze-drying onsite, enables greater customisation of solutions, tailoring enzyme formulations specific to customer and industry needs to offer flexibility and precision in enzyme formulation.
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2 Mar 2023
Biocatalysts Ltd launch Nuclease for the growing precision fermentation market
Nuclease 46L has been designed specifically as a cost-effective solution for the elimination of nucleic acids in a wide range of biotechnology applications.
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25 Jul 2022
Precision Fermentation – a bio-based route to alternative protein
Nutrition in industrialised countries will move away from meat and dairy consumption towards alternative sources of protein and foods. These will rely on plants, microorganisms and cell cultures. Biotechnology will be the key enabler. This is where we come in.
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Biocatalysts Ltd 2021 EMP Feed Tanks Copyrighted 2
14 Oct 2021
Biocatalysts Ltd Announce Plans for Further Investment for Second 10m³ Fermenter in Cardiff
The introduction of a second 10m³ fermenter enables Biocatalysts Ltd.’s manufacturing site in Cardiff to act as a pilot plant for medium-scale production and optimised tech-transfer for larger industrial scale fermentation.
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Sugar reduction reduced
Case Study
Novel enzyme used in carbohydrate modification produced in partnership with sugar reduction company.
Working in close partnership we were able to rapidly scale up their process to produce the enzyme at commercial volumes enabling them to reduce the time to market for their unique offering into this exciting fast-moving sector.
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Biocatalysts Ltd 2021 EMP Full Facility
11 Aug 2021
Project Completion & Successful Commissioning of Biocatalysts Ltd's New Enzyme Manufacturing Facility
Operations Director, Craig Galeozzie provides a final update following the successful project completion and commissioning of the new state-or-the-art enzyme manufacturing facility.
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Biocats website Market Sectors
13 May 2021
Biocatalysts Ltd First Commercial Production in New Enzyme Manufacturing Facility
Key milestone achieved with the first product fermented and processed in the state-of-the-art enzyme manufacturing facility is delivered to the customer.
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Case Study
Introducing a NEW Expression Host – Yarrowia lipolytica
Expression strain developments increase Biocatalysts' enzyme development and manufacture service offering
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Global Awards FOODDRINK 2020
4 Nov 2020
Winners of Prestigious IChemE Global Food & Drink Award 2020
IChemE have selected Biocatalysts Ltd in partnership with University College London (UCL) as the winners of the prestigious IChemE Global Food & Drink Award 2020, for our submission – Ultra Scale-Down Accelerates Industrial Enzyme Manufacture.
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18 Jun 2020
Biocatalysts’ Various Protein Production Hosts for Optimising Expression
At Biocatalysts we are able to offer highly versatile protein production hosts to address our customers’ needs and develop our own novel enzymes.
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Biocats website About us 2
Case Study
Partnering with a Global Pharmaceutical Company for Large Scale Enzyme Manufacturing
A large pharmaceutical company needed an enzyme manufacturing partner to develop their enzymes from lab to commercial scales.
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