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Strain Development

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It all starts with the strain
In fermentation, the production strain means everything. Whether you're looking to identify a suitable microbial strain for your application or to optimise a microbe already in use, our expertise and know-how in discovering and optimising microbial strains can develop a solution fit for your project.

Fermentation as a scalable technology starts with the microorganisms that act as factories in which cells are capable of producing very precise ingredients through very rapid duplication. Fermenting enzymes requires the synergy between protein of interest and microorganisms. Different enzyme classes, and even different classes of enzymes from the same class, are known to be better suited to specific microorganisms. To achieve optimum production yield of the enzyme, genetic engineering or evolutionary optimisation methods can be explored to best reach target strain productivity.

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For the production of enzymes and proteins, we access prokaryotic host organisms (including Escherichia coli, Bacillus subtilis, Pseudomonas stutzeri, Streptomyces lividans and Corynebacterium glutamicum) and eukaryotic host organisms (including Pichia pastoris, Kluyveromyces lactis and Aspergillus niger). For the expression of a gene of interest, the gene can be inserted into an expression host via BRAIN’s metagenomic Cas nuclease BMC (proprietary CRISPR-Cas) or classical methods utilising different auxotrophic and antibiotic selection markers.

Our USPs in microbial strain development:

  • Own Bioarchive with thousands of microorganisms
  • Application-specific microbial toolboxes of value-added strains with defined properties
  • Long-standing experience in strain development working on many types of producer strains
  • Broad application knowledge in different industries
  • Comprehensive technology package of microbiology, molecular biology, bioinformatics, assay development, analytics, and bioprocess development
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20 A1336
1 Oct 2024
BRAIN Biotech AG and Biocatalysts Ltd Launch a New Business Initiative to Revolutionise Enzyme Solutions within the Life Science Industry
Combining cutting-edge enzyme discovery, optimisation, and large-scale manufacturing to offer an end-to-end solution for the life sciences industry. BRAIN-Biocatalysts Life Science Solutions addresses critical gaps in the market, providing tailored enzyme solutions with a transparent IP strategy that ensures partners retain full control over their innovations.
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Application Solution
Unlocking the benefits of plant oil hydrolysis
Free fatty acids, the fundamental building blocks in many sectors, can vary in chain length and degree of saturation, influencing their functionality and applications. However, the industry has long faced challenges in maximising the yield of free fatty acids while maintaining cost efficiency and environmental sustainability.
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16 Sept 2024
Biocatalysts Ltd Launches Lipomod™ 70MDP - Setting A New Standard To Deliver Sustainable Solutions for Oleochemicals Industry with Maximal Production Efficiency
Achieve superior hydrolysis unseen in the market for breaking down plant-derived oils into valuable by-products like glycerol and fatty acids
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30 Aug 2024
BRAIN Biotech AG presents strong cash position with its 9M reporting and is forecasting good sequential growth in the final quarter of the business year
BRAIN Biotech AG, a leading provider of integrated solutions for the biologisation of industry, today published its 9M results of FY2023/2024.
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22 Aug 2024
BRAIN Biotech launches MetXtra™
Designed to establish and optimise biocatalytic processes, develop novel enzyme solutions and generate IP or FTO for customers, the cutting edge technologies of MetXtra™ unlock the secrets of the unexplored sequence space.
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30 Jul 2024
Biocatalysts Ltd launches new "Plug & Produce" production strains significantly reducing scale-up time and cost
Developing enzyme and protein fermentation processes can be long and expensive and is often reliant on a single partner. Our proprietary "Plug & Produce" platform of microbial fermentation strains can bring product to market quicker, reduce cost and reduce supply chain risk.
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23 Jul 2024
The Crucial Role of Phenylalanine Dehydrogenase in Detecting Phenylketonuria
Phenylketonuria (PKU) is genetic disorder resulting from a deficiency in the enzyme phenylalanine hydroxylase for the conversion of the amino acid, phenylalanine to tyrosine. This condition can cause phenylalanine accumulation in the blood and result in neurological damage if left untreated or undiagnosed. Read about the highly specific and sensitive enzymatic method for early detection of PKU.
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10 Jun 2024
Enzymes: The Eco-Warriors of Food Manufacturing
As companies increasingly prioritise sustainability, enzymes emerge as unknown heroes, quietly revolutionising the way we produce food.
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4 Jun 2024
The Power of Enzymes: Why Hydrolysing Proteins Matters
In the world of biology and biochemistry, the process of hydrolysing proteins using enzymes plays a crucial role in industrial applications, with significant environmental benefits.
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30 May 2024
BRAIN Biotech AG receives major milestone payment and stays on-track to achieve year end targets
Parent company BRAIN Biotech AG, a leading provider of integrated solutions for the biologisation of industry, today published its half year results, 6M 2023/2024.
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28 May 2024
Biocatalysts Ltd Introduce Unique Protease Platform for the Manufacture of High Value Collagen Peptides
The launch of two unique protease enzymes, Promod™ 327L and Promod™ 295L, deliver significant efficiency and precision in collagen processing, optimising taste, texture and processibility.
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20 May 2024
Biocatalysts Ltd Completes Scale Up of Speciality Enzyme for Large Pharmaceutical Company Utilising its New Chromatography Facility
Newly installed advanced chromatography system at Cardiff site enables the production of high-purity speciality enzymes.
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