Developing Powerful Production Strains

For high productivity of an enzyme in fermentation, different microorganisms are better suited to different proteins of interest. Aligning the protein of interest to a suitable microorganism is a step in the right direction of a commercially viable process and product. The proprietary Bioarchive can be screened to specific parameters to identify a shortlist of suitable microorganisms that can be characterised by microbiological techniques as well as genome analysis and growth and performance tests under application-specific conditions.

For more information on microorganism discovery capabilities and technologies click here

We have the technologies and experience to support microbial strain development from diverse genetic engineering methodologies (e.g. proprietary CRISPR-Cas) as well as adaptive laboratory evolution (ALE) techniques.

Interested in learning more about our optimisation techniques, read more here.

All of our research and development work is planned and executed with scalability in mind. We know your innovations are destined for commercial applications and so we ensure at every step of the way we develop a process and product that can be reproduced at commercial volumes. At this stage we take the developed and optimised production strain that we know works on laboratory scale, and begin to scale up the microbial production process to pilot- and industrial scale. Using biology and engineering skills and broad knowledge of process development, we set up upstream and downstream processes in close collaboration with customers. For a process transfer, processes can be scaled and optimised up to 200 litres at our BRAIN R&D innovation centre in Zwingenberg, Germany, with additional larger scale capacities seamlessly transferred to our manufacturing and state-of-the-art fermentation facility in Cardiff, United Kingdom.

Click here for more information on scaling up at larger scales in our fermentation facility in the UK.