No One Can Do What We Do
Our Enzyme Development & Manufacturing business model is cutting edge – this service has been successfully used for various applications in a number of different industries e.g. food, flavour & fragrance, life science, pharma, fine chemicals and more.
Read moreNo One Can Do What We Do
We’re an enzyme development and manufacturing company who is leading the way in the enzyme world. How? We are unique in the way that we are able to take an enzyme from concept to routine manufacture in less than 12 months.
Our 30 years of experience in the industry means that we have the ability to discover and develop customised enzyme solutions to suit your needs. We possess the tools, expertise and capabilities to carry out this enzyme manufacturing process as cost effectively, quickly and simply as possible, without compromising on quality. In fact customers are often in disbelief when we provide a timeframe of a sample of a novel enzyme. However, we can and do deliver on time, which in turn, benefits our customers’ product or process development.
Amongst our many capabilities is our own metagenomic library, protein synthesiser, bioinformatics and cloning, downstream processing and enzyme stabilisation, to name but a few. In fact we have over 80 different capabilities that we utilise depending on the type of project we are undertaking. Take a look at our A-Z of capabilities.
Primarily, our customers look to use a speciality enzyme to solve a specific problem, facilitate specific biochemical reactions to produce a unique product, or to save money by utilising a waste stream. If a solution doesn’t sit within our off-the-shelf range, we can create a customised enzyme solution for you, driving down costs and timescales. This sets us apart from our competitors.
When exploring enzyme solutions, we use our ‘Design for Manufacture’ approach, taking into consideration all the potential limitations, including regulatory, technical and commercial issues at the beginning of the project. We then use our experience to resolve these issues during the enzyme development process. This can be completed in less than 12 months, allowing us to exceed our customers’ enzyme expectations.
Our world class customer service reputation is proof that whilst we are able to successfully produce both standard and novel enzymes, we’re also able to deliver excellent customer service too, working closely with our customers throughout the enzyme manufacturing process.
We’re one of the only companies that can discover, develop and routinely manufacture and supply truly unique enzyme products. If you want a tailored and exclusive product from one of the leading enzyme manufacturing companies, look no further than Biocatalysts.
For more information take a look at this video, where our Enzyme Development & Manufacture Coordinator, Menna Thomas, talks about our unique capabilities. You will also get chance to take a glance in our production facilities:
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View articleThe Enzyme Development & Manufacture Process

Desk Based Feasibility
The first stage in this process involves assessing the feasibility of the whole project not just technically, but commercially. As an enzyme development and manufacturing company, our overall aim is to provide a continuous supply of your desired novel enzyme at the right price.
Our commercially focused approach, from concept to routine manufacture of bespoke enzyme products, enables us to mitigate risks by developing an enzyme process that is technically and commercially robust. We call this our“Design for Manufacture” approach.
The effectiveness of our “Design for Manufacture” approach is highlighted here, as the sample will be developed using techniques which are fully scalable. Our analysis of the technical aspects of the enzyme use actual production data from our production plant rather than theoretical maxima. This provides peace of mind for the customer.
These projects are run by a team of qualified project managers together with PhD level molecular biologists and fermentation scientists who have many years of enzyme experience.

Bioinformatics, Cloning & Metagenomics
Find the right enzyme for your process by using Biocatalysts’ in-house enzyme discovery technology.
It’s estimated that ~ 99% of microbial life cannot yet be cultured in the lab. Have you heard this said? This tells us that there is a wealth of untapped biological diversity in the microbial world.
At Biocatalysts, we have our own Metagenomics Library that allows us to access an abundance of previously unexplored enzyme sequences.
This is a unique and valuable resource for enzyme discovery that, combined with our novel bioinformatics platform, can rapidly identify panels of variants of your enzyme that we can synthesise and provide to you for testing.
Biocatalysts’ approach to providing panels of enzyme samples from metagenomic analysis is highly customer focused. We work with each individual customer to understand their specific requirements and specifications to then target our bioinformatics platform to search our metagenomics libraries based upon these details.
This provides a bespoke panel of enzyme samples with a higher chance of successfully delivering the required enzyme properties to the customer.
Are you looking for an enzyme active at a higher than usual pH, have a certain substrate specificity in mind or require optimum activity at an extremely low temperature? Our metagenomic library could hold the answer!
We have sourced our metagenomic library from diverse environmental localities comprising acid/alkaline. hot/cold, arid, wet, saline etc.

Research Grade Sample Service for Fast & Cost-effective Enzyme Discovery
A bespoke panel of up to 20 enzymes, suited to individual customer needs, can be provided ready for testing in just 11 weeks.
Biocatalysts’ new Research Grade Sample Service has been developed to help our customers discover new enzymes in a fast and cost-effective manner. The bespoke panels comprise of enzymes identified from a variety of sources, primarily our own metagenomic library, that can be tested in your application. Each enzyme sample is delivered as ~0.5 – 1g of freeze dried powder along with reconstitution instructions and a data sheet. This service enables you to identify and test unique enzymes, that you previously wouldn’t be able to access, without a large investment of time or money. This allows you to innovate for emerging industry trends, get your new products to market quicker and gain competitive advantage within your industry.

Enzyme Samples
Biocatalysts can turn a concept into a reality in just 8 weeks, delivering a sample of active, soluble enzyme along with a technical summary and specification.
Having a small sample of the enzyme allows you to assess whether the enzyme does what it needs to do. Typically produced from laboratory scale fermentations, this is the first step in designing a fully scalable manufacturing process for your enzyme.
This enzyme sample will be provided with an activity specification, using over 30 years of Biocatalysts assay validation skills. It is also possible to develop a full activity specification if required.
The short timescale on our sample service, compared to the typical 18 month timescale of other enzyme manufacturing companies, ultimately reduces your time to market, allowing for your unique product to be developed and begin delivering profit when you want it.

Fermentation Development, Optimisation & Scale-up
Now that the enzyme has been shown to perform as expected, the final stage involves making the product fit your commercial requirements.
As a leading enzyme development and manufacturing company, we believe the best conditions for the process are identified using a combination of “Design of Experiment” and state of the art parallel micro-fermentation technology. These conditions are then confirmed on a larger scale. This stage only takes 8-12 weeks.
The overall output is a fully scalable, optimised enzyme production process which is designed for routine manufacture. At the end of this stage, the enzyme can be produced at commercial volumes.

Validation, Regulations, Quality Assurance and Routine Manufacture
The output of our unique enzyme development and manufacturing process is the routine manufacture or supply of your exclusive and commercially viable enzyme. This includes all the benefits of being a Biocatalysts standard enzyme product:
Fully confidential service
Exclusivity
Global shipment
Regulatory support
Kosher & Halal certified manufacturing facilities
Full certification & quality control
Technical support
Stabilisation
As part of our enzyme manufacturing process the enzyme will go through an appropriate pilot scale (500 – 3,000L). We have a fermentation capacity of up to 20,000L and full downstream processing capabilities to ensure your desired scale is achieved. The output of this stage is fully saleable product.